Viagra Overdosage & Contraindications

OVERDOSE
In studies with advantageous volunteers of individual doses up to 800 mg, adverse contest were agnate to those apparent at lower doses but accident ante were increased.
In cases of overdose, accepted admiring measures should be adopted as required. Renal dialysis is not accepted to advance approval as sildenafil is awful apprenticed to claret proteins and it is not alone in the urine.
CONTRAINDICATIONS
Consistent with its accepted furnishings on the nitric oxide/cGMP alleyway (see CLINICAL PHARMACOLOGY), VIAGRA was apparent to potentiate the hypotensive furnishings of nitrates, and its administering to patients who are application amoebic nitrates, either consistently and/or intermittently, in any anatomy is accordingly contraindicated.
After patients accept taken VIAGRA, it is alien if nitrates, if necessary, can be cautiously administered. Based on the pharmacokinetic contour of a individual 100 mg articulate dosage accustomed to advantageous accustomed volunteers, the claret levels of sildenafil at 24 hours column dosage are about 2 ng/mL (compared to aiguille claret levels of about 440 ng/mL) (see CLINICAL PHARMACOLOGY: Pharmacokinetics and Metabolism). In the afterward patients: age > 65, hepatic crime (e.g., cirrhosis), astringent renal crime (e.g., creatinine approval < 30 mL/min), and accessory use of almighty cytochrome P450 3A4 inhibitors (erythromycin), claret levels of sildenafil at 24 hours column dosage accept been begin to be 3 to 8 times college than those apparent in advantageous volunteers. Although claret levels of sildenafil at 24 hours column dosage are abundant lower than at aiguille concentration, it is alien whether nitrates can be cautiously coadministered at this time point.
VIAGRA is contraindicated in patients with a accepted hypersensitivity to any basic of the tablet.